The San Diego Twin Program

Based at the University of California-San Diego

and

VA San Diego Healthcare System.

Coinvestigators: Drs. Daniel T. O’Connor, Nicholas A. Schork, Elizabeth O. Lillie, Guangfa Zhang.

Goals:

We study heredity and blood pressure, in individuals with either normal or elevated blood pressure. We are looking at very early traits (or "phenotypes") whereby the unconscious (autonomic) nervous system and the kidney start to malfunction in hypertension, even before the blood pressure is elevated. Twins, whether normotensive or hypertensive, allow us to study the heredity of such traits, and to map the genes influencing those traits. If the trait similarity (correlation, or R value) is greater in identical (MZ) than in fraternal (DZ) twins, the information can be used to compute heritability (h2) mathematically. Simply put: h2 = 2(RMZ - RDZ).

Twin recruitment:

ARE YOU A TWIN?

WE'RE LOOKING FOR TWINS FOR A STUDY AT UCSD!

UCSD researchers would like to meet people who are twins, for a brief study on how heredity influences blood pressure in healthy persons. Because twins share genes, twin pairs allow us to evaluate readily how heritability influences traits. We seek both identical ("monozygotic") and fraternal ("dizygotic") twin pairs. We seek twins of either sex, ages 18 years and over, and all ethnic groups or races.

The study takes about 40 minutes, and includes measurement of blood pressure and heart rate, as well as taking a blood and urine sample. We will provide monetary compensation for your time and travel.

If you and your twin would like to find out more about this study, please contact:

Elizabeth (Betsy) O. Lillie, Ph.D.
Postdoctoral Scholar
University of California at San Diego
Department of Medicine and VA Medical Center (111M-1)
3350 La Jolla Village Drive San Diego, CA 92161
Tel: (858) 552-8585, ext. 6158
Fax: (858) 642-6338
Email: elillie@ucsd.edu

   ¿ES USTED UN GEMELO?

¡ESTAMOS BUSCANDO GEMELOS PARA UN ESTUDIO EN UCSD!

Somos investigadores de UCSD que nos gustaría encontrar individuos son gemelos(as), para un breve estudio de cómo la herencia influye en la presión arterial de personas saludables. Puesto que los gemelos comparten genes, estos nos permiten evaluar rápidamente cómo la herencia influye en estos rasgos. Buscamos tanto a gemelos idénticos ("monocigoticos"), como fraternales ("dicigoticos").Así como a gemelos de cualquier sexo, de 18 años o mayores y de cualquier grupo étnico o raza.

El estudio toma aproximadamente 40 minutos, e incluye la evaluación de la presión arterial y frecuencia cardiaca, así como una muestra de sangre y orina. Compensaremos monetariamente su tiempo y viaje.

Si a usted y a su gemelo les gustara averiguar más sobre este estudio, favor llamar a:

Elizabeth (Betsy) O. Lillie, Ph.D.
Postdoctoral Scholar
University of California at San Diego
Department of Medicine and VA Medical Center (111M-1)
3350 La Jolla Village Drive San Diego, CA 92161
Teléfono (858)-552-8585, extensión 6158
Fax: (858) 642-6338
Correo electrónico: elillie@ucsd.edu